Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data
Representative 1H NMR (500 MHz) spectrum confirming the structure of OM173-alphaA. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of OM173-alphaA.
Source Organism
Streptomyces rosa subsp. Notoensis
Summary
OM173-alphaA is a nanaomycin-type polyketide antibiotic active against mycoplasmas and fungi.
Details
OM173-alphaA is one of several nanaomycin-type antibiotics produced by Streptomyces sp. OM-173. Structurally belonging to the benzoisochromanequinone family of polyketide-derived antibiotics, it shares biosynthetic homology with actinorhodin- and kalafungin-type compounds. OM173-alphaA exhibits activity against mycoplasmas and moderate antifungal effects, consistent with quinone-containing redox-active antibiotics. Biosynthetic gene cluster analysis indicates PKS-derived assembly closely related to nanaomycin and kalafungin pathways. The compound represents a useful scaffold for studying polyketide quinone antibiotic biosynthesis and redox-mediated antimicrobial mechanisms.