Name: Concanamycin B
Brand: Biolinks K.K.
SKU: BLK-1160
Price: 360.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Concanamycin B (CAS: 81552-33-2) Product ID: BLK-1160 CAS 81552-33-2 Mechanism V-ATPase inhibitor Primary Target Vacuolar-type H+-ATPase (V-ATPase) Pathway Endosomal–lysosomal acidification pathway
Structure	View full structure page Chemical structure of Concanamycin B (CAS 81552-33-2)
CAS	81552-33-2
Molecular Formula	C45H73NO14
Molecular Weight	852.08
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Concanamycin B. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Concanamycin B.
Source Organism	Streptomyces sp.
Summary	Concanamycin B is a V-ATPase–specific macrolide inhibitor that blocks lysosomal acidification.
Details	Concanamycin B is an 18-membered macrolide antibiotic isolated from Streptomyces diastatochromogenes and belongs to the concanamycin/folimycin family. It specifically inhibits vacuolar-type H+-ATPase (V-ATPase), thereby preventing ATP-dependent acidification of endosomes, lysosomes, and osteoclastic resorption lacunae. Through inhibition of organelle acidification, concanamycin B suppresses antigen presentation via MHC class II and blocks osteoclast-mediated bone resorption. It is widely used as a mechanistic probe to study vesicular trafficking, receptor recycling, lysosomal function, and pH-dependent cellular processes.
Browse Related	Mechanism V-ATPase inhibitor Open full index Primary Target Vacuolar-type H+-ATPase (V-ATPase) Open full index Pathway Endosomal–lysosomal acidification pathway Open full index Chemical Class 18-membered macrolide Open full index
Mechanism	V-ATPase inhibitor
Primary Target	Vacuolar-type H+-ATPase (V-ATPase)
Pathway	Endosomal–lysosomal acidification pathway
Chemical Class	18-membered macrolide
Discovery Year	1984
Keywords	v-atpase inhibitor macrolide antibiotic proton pump inhibitor endosomal acidification blocker lysosomal ph modulator osteoclast activity inhibitor fungal-active antibiotic cell biology mechanistic probe
References	Kinashi et al., J Antibiot, 1984 DOI: 10.7164/antibiotics.37.1333 Nishimura et al., Biol Pharm Bull, 1996 DOI: 10.1248/bpb.19.297 Kuwana et al., J Antibiot, 1995 DOI: 10.7164/antibiotics.48.488 Uchida et al., Eur J Biochem, 1992 DOI: 10.1111/j.1432-1033.1992.tb17061.x
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Concanamycin B (CAS: 81552-33-2)