Name: epi-Aszonalenin A
Brand: Biolinks K.K.
SKU: BLK-1150
Price: 120.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

epi-Aszonalenin A Product ID: BLK-1150 Mechanism NF-κB pathway inhibitor Primary Target LOX-1; NF-κB; VEGFR-2 Pathway Inflammatory signaling pathway; Angiogenesis pathway
Structure	View full structure page Chemical structure of epi-Aszonalenin A (CAS )
Molecular Formula	C25H25N3O3
Molecular Weight	415.49
Price	1mg: USD 120.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of epi-Aszonalenin A. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of epi-Aszonalenin A.
Source Organism	Neosartorya fischeri.
Summary	epi-Aszonalenin A is a fungal indole alkaloid that inhibits inflammation and angiogenesis.
Details	epi-Aszonalenin A is a prenylated indole alkaloid isolated from Aspergillus species. It suppresses ox-LDL-induced inflammation, angiogenesis, and apoptosis in HUVEC cells by downregulating LOX-1 expression and inhibiting NF-κB, PI3K/AKT, and MAPK signaling pathways. These properties suggest potential applications in atherosclerosis and vascular inflammation research.
Browse Related	Mechanism NF-κB pathway inhibitor Open full index Primary Target LOX-1; NF-κB; VEGFR-2 Open full index Pathway Inflammatory signaling pathway; Angiogenesis pathway Open full index Chemical Class Prenylated indole alkaloid Open full index
Mechanism	NF-κB pathway inhibitor
Primary Target	LOX-1; NF-κB; VEGFR-2
Pathway	Inflammatory signaling pathway; Angiogenesis pathway
Chemical Class	Prenylated indole alkaloid
Discovery Year	2015
Keywords	lox-1 inhibitor nf-κb pathway inhibitor anti-angiogenic compound pi3k akt pathway modulator mapk signaling modulator indole alkaloid fungal metabolite atherosclerosis research tool
References	Zhang et al., Int Immunopharmacol, 2022 DOI: 10.1016/j.intimp.2022.108931 Miyamoto et al., Nat Prod Res, 2015 DOI: 10.1080/14786419.2015.1101107
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Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.