Name: Quinolactacin A
Brand: Biolinks K.K.
SKU: BLK-1140
Price: 120.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Quinolactacin A Product ID: BLK-1140 Mechanism TNF-alpha production inhibitor Primary Target Tumor necrosis factor alpha (TNF-α) Pathway LPS-induced TNF signaling pathway
Structure	View full structure page Chemical structure of Quinolactacin A (CAS )
Molecular Formula	C16H18N2O2
Molecular Weight	270.33
Price	1mg: USD 120.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Quinolactacin A. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Quinolactacin A.
Source Organism	Penicillium citrinum.
Summary	Quinolactacin A is a fungal 4-quinolone metabolite that inhibits TNF production.
Details	Quinolactacin A is a secondary metabolite produced by Penicillium species and structurally classified as an N-methyl-4-quinolone conjugated with a γ-lactam moiety. It was originally identified as a potent inhibitor of tumor necrosis factor (TNF)-α production in lipopolysaccharide-stimulated murine macrophages. Isotope-labeling studies clarified its biosynthetic origin from acetate, anthranilate, isoleucine, and methionine precursors. Subsequent heterologous expression and enzymatic reconstitution revealed a concise nonribosomal peptide synthetase (NRPS)-dependent pathway responsible for quinolactacin assembly.
Browse Related	Mechanism TNF-alpha production inhibitor Open full index Primary Target Tumor necrosis factor alpha (TNF-α) Open full index Pathway LPS-induced TNF signaling pathway Open full index Chemical Class 4-Quinolone γ-lactam Open full index
Mechanism	TNF-alpha production inhibitor
Primary Target	Tumor necrosis factor alpha (TNF-α)
Pathway	LPS-induced TNF signaling pathway
Chemical Class	4-Quinolone γ-lactam
Discovery Year	2000
Keywords	tnf production inhibitor 4-quinolone natural product lipopolysaccharide response inhibitor penicillium metabolite nrps-derived metabolite anti-inflammatory research tool
References	Kobayashi et al., J Antibiot, 2000 DOI: 10.7164/antibiotics.53.1247 Kobayashi et al., J Antibiot, 2006 DOI: 10.1038/ja.2006.59 Ye et al., Org Lett, 2020 DOI: 10.1021/acs.orglett.0c02426
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Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.