Name: Aranorosin
Brand: Biolinks K.K.
SKU: BLK-1050
Price: 140.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Aranorosin (CAS: 117184-53-9) Product ID: BLK-1050 CAS 117184-53-9 Mechanism Apoptosis inducer Primary Target Bcl-2 Pathway Mitochondrial apoptosis pathway
Structure	View full structure page Chemical structure of Aranorosin (CAS 117184-53-9)
CAS	117184-53-9
Molecular Formula	C23H33NO6
Molecular Weight	419.52
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Aranorosin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Aranorosin.
Source Organism	Gymnascella sp.
Summary	Aranorosin is a fungal antibiotic that exhibits antifungal activity and modulates Bcl-2–regulated apoptotic signaling.
Details	Aranorosin is a novel antibiotic isolated from the fermentation broth of Pseudoarachniotus roseus. Structurally, it contains a unique 1-oxaspiro[4,5]decane ring system. Initially characterized for its antifungal activity, aranorosin was later identified as an inhibitor of Bcl-2-regulated anti-apoptotic functions. It promotes mitochondrial outer membrane permeabilization, induces loss of mitochondrial membrane potential, activates caspase-9, and enhances apoptosis in Bcl-2-overexpressing cells. These findings position aranorosin as a natural product scaffold of interest for apoptosis-targeted anticancer research.
Browse Related	Mechanism Apoptosis inducer Open full index Primary Target Bcl-2 Open full index Pathway Mitochondrial apoptosis pathway Open full index Chemical Class Spirocyclic polyketide Open full index
Mechanism	Apoptosis inducer
Primary Target	Bcl-2
Pathway	Mitochondrial apoptosis pathway
Chemical Class	Spirocyclic polyketide
Discovery Year	1988
Keywords	bcl-2 pathway inhibitor apoptosis inducer mitochondrial apoptotic pathway activator antifungal antibiotic spirocyclic natural product pseudoarachniotus metabolite apoptosis research tool
References	Umezawa H et al., J Antibiot (Tokyo), 1988, 41:1780-1784 DOI: 10.7164/antibiotics.41.1780 Umezawa H et al., J Antibiot (Tokyo), 1988, 41:1785-1792 DOI: 10.7164/antibiotics.41.1785 Saito Y et al., Biochem Biophys Res Commun, 2009, 379:76-80 DOI: 10.1016/j.bbrc.2008.10.112
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Aranorosin (CAS: 117184-53-9)