Name: Amauromine
Brand: Biolinks K.K.
SKU: BLK-1040
Price: 140.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Amauromine (CAS: 88360-87-6) Product ID: BLK-1040 CAS 88360-87-6 Mechanism GPCR antagonist Primary Target Cannabinoid CB1 receptor; GPR18 Pathway GPCR signaling pathway; Vascular tone regulation; Cannabinoid receptor signaling
Structure	View full structure page Chemical structure of Amauromine (CAS 88360-87-6)
CAS	88360-87-6
Molecular Formula	C32H36N4O2
Molecular Weight	508.66
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Amauromine. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Amauromine.
Source Organism	Gymnascella sp.
Summary	Amauromine is a fungal diketopiperazine alkaloid that modulates GPCR signaling by inhibiting CB1 and GPR18 receptors.
Details	Amauromine is a fungal-derived diketopiperazine alkaloid originally isolated from Amauroascus sp. as a vasodilatory compound with low acute toxicity in mice. Structural characterization established the molecular formula C32H36N4O2. Subsequent studies revealed that amauromine acts as a cannabinoid receptor antagonist, inhibiting CB1 receptors (Ki = 0.178 µM) and exhibiting antagonistic activity at the orphan receptor GPR18 (IC50 = 3.74 µM), thereby identifying it as a bioactive GPCR modulator. Related diketopiperazine analogues isolated from Aspergillus terreus showed α-glucosidase inhibitory activity, further supporting the pharmacological relevance of this structural class. These data establish amauromine as a multifunctional fungal alkaloid with vasodilatory and receptor-modulating properties and potential utility as a lead structure for GPCR-targeted research.
Browse Related	Mechanism GPCR antagonist Open full index Primary Target Cannabinoid CB1 receptor; GPR18 Open full index Pathway GPCR signaling pathway; Vascular tone regulation; Cannabinoid receptor signaling Open full index Chemical Class Diketopiperazine alkaloid Open full index
Mechanism	GPCR antagonist
Primary Target	Cannabinoid CB1 receptor; GPR18
Pathway	GPCR signaling pathway; Vascular tone regulation; Cannabinoid receptor signaling
Chemical Class	Diketopiperazine alkaloid
Discovery Year	1984
Keywords	cannabinoid cb1 receptor antagonist gpr18 antagonist gpcr modulator vasodilatory activity α-glucosidase inhibitor diketopiperazine alkaloid fungal metabolite gpcr signaling research tool
References	Kobayashi H et al., J Antibiot (Tokyo), 1984, 37:1320-1327 DOI: 10.7164/antibiotics.37.1320 Pacher T et al., Chem Biodivers, 2015, 12(7):1049-1056 DOI: 10.1002/cbdv.201500027
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Amauromine (CAS: 88360-87-6)