Name: Chartreusin
Brand: Biolinks K.K.
SKU: BLK-1030
Price: 50.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Chartreusin (CAS: 6377-18-0) Product ID: BLK-1030 CAS 6377-18-0 Mechanism DNA-binding antibiotic Primary Target GC-rich B-DNA Pathway DNA transcription; Topoisomerase II-associated DNA damage
Structure	View full structure page Chemical structure of Chartreusin (CAS 6377-18-0)
CAS	6377-18-0
Molecular Formula	C32H32O14
Molecular Weight	640.6
Price	1mg: USD 50.00 / 5mg: USD 120.00 / 25mg: -
Storage	-20°C
Solubility	1mg/ml Acetone
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Data	1H NMR (DMSO-d6, 500 MHz) [View] [Full page]
NMR Spectral Data	Representative 1H NMR (DMSO-d6, 500 MHz) spectrum confirming the structure of Chartreusin. Representative 13C NMR (DMSO-d6, 125 MHz) spectrum supporting structural assignment of Chartreusin.
Source Organism	Streptomyces sp.
Summary	Chartreusin is a Streptomyces-derived chromoglycoside antibiotic that binds GC-rich DNA and is used in antitumor research.
Details	Chartreusin is an aromatic chromoglycoside polyketide antibiotic originally isolated from Streptomyces chartreusis. It selectively binds GC-rich regions of B-DNA, inhibits RNA synthesis, and induces oxidative single-strand DNA scission. These DNA-directed effects result in antiproliferative activity and have driven development of semi-synthetic derivatives with improved pharmacokinetics. Chartreusin remains a valuable mechanistic probe for studying transcription inhibition and DNA-damage-mediated cytotoxicity.
Browse Related	Mechanism DNA-binding antibiotic Open full index Primary Target GC-rich B-DNA Open full index Pathway DNA transcription; Topoisomerase II-associated DNA damage Open full index Chemical Class Chromoglycoside polyketide (type II PKS) Open full index
Mechanism	DNA-binding antibiotic
Primary Target	GC-rich B-DNA
Pathway	DNA transcription; Topoisomerase II-associated DNA damage
Chemical Class	Chromoglycoside polyketide (type II PKS)
Discovery Year	1953
Keywords	gc-rich dna-binding antibiotic chromoglycoside polyketide topoisomerase ii inhibitor transcription inhibitor streptomyces metabolite antitumor research tool dna-interaction probe
References	Leach et al., J Am Chem Soc, 1953 DOI: 10.1021/ja01112a040 Portugal et al., Curr Med Chem Anti-Cancer Agents, 2003 DOI: 10.2174/1568011033482215 Zhu et al., Ann Transl Med, 2020 DOI: 10.21037/atm.2020.03.227 Xu et al., Angew Chem Int Ed, 2022 DOI: 10.1002/anie.202112047
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.
Representative NMR Data 1H NMR (DMSO-d6, 500 MHz) Representative spectral data. Actual batch data may vary.

Chartreusin (CAS: 6377-18-0)