Name: Chartreusin
Brand: Biolinks K.K.
SKU: BLK-1030
Price: 50.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Chartreusin (CAS: 6377-18-0) Product ID: BLK-1030 CAS 6377-18-0 Mechanism DNA-binding antibiotic Primary Target GC-rich B-DNA Pathway DNA transcription; Topoisomerase II-associated DNA damage
Structure	View full structure page Chemical structure of Chartreusin (CAS 6377-18-0)
CAS	6377-18-0
Molecular Formula	C32H32O14
Molecular Weight	640.6
Price	1mg: USD 50.00 / 5mg: USD 120.00 / 25mg: -
Storage	-20°C
Solubility	1mg/ml Acetone
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Chartreusin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Chartreusin.
Source Organism	Streptomyces sp.
Summary	Chartreusin is a Streptomyces-derived chromoglycoside antibiotic that binds GC-rich DNA and is used in antitumor research.
Details	Chartreusin is an aromatic chromoglycoside polyketide antibiotic originally isolated from Streptomyces chartreusis. It selectively binds GC-rich regions of B-DNA, inhibits RNA synthesis, and induces oxidative single-strand DNA scission. These DNA-directed effects result in antiproliferative activity and have driven development of semi-synthetic derivatives with improved pharmacokinetics. Chartreusin remains a valuable mechanistic probe for studying transcription inhibition and DNA-damage-mediated cytotoxicity.
Browse Related	Mechanism DNA-binding antibiotic Open full index Primary Target GC-rich B-DNA Open full index Pathway DNA transcription; Topoisomerase II-associated DNA damage Open full index Chemical Class Chromoglycoside polyketide (type II PKS) Open full index
Mechanism	DNA-binding antibiotic
Primary Target	GC-rich B-DNA
Pathway	DNA transcription; Topoisomerase II-associated DNA damage
Chemical Class	Chromoglycoside polyketide (type II PKS)
Discovery Year	1953
Keywords	gc-rich dna-binding antibiotic chromoglycoside polyketide topoisomerase ii inhibitor transcription inhibitor streptomyces metabolite antitumor research tool dna-interaction probe
References	Leach et al., J Am Chem Soc, 1953 DOI: 10.1021/ja01112a040 Portugal et al., Curr Med Chem Anti-Cancer Agents, 2003 DOI: 10.2174/1568011033482215 Zhu et al., Ann Transl Med, 2020 DOI: 10.21037/atm.2020.03.227 Xu et al., Angew Chem Int Ed, 2022 DOI: 10.1002/anie.202112047
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Chartreusin (CAS: 6377-18-0)