Name: Terpendole C
Brand: Biolinks K.K.
SKU: BLK-0990
Price: 220.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Terpendole C (CAS: 156967-65-6) Product ID: BLK-0990 CAS 156967-65-6 Mechanism ACAT inhibitor Primary Target Acyl-CoA:cholesterol acyltransferase (ACAT) Pathway Cholesterol esterification pathway
Structure	View full structure page Chemical structure of Terpendole C (CAS 156967-65-6)
CAS	156967-65-6
Molecular Formula	C32H41NO5
Molecular Weight	519.68
Price	1mg: USD 220.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Terpendole C. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Terpendole C.
Source Organism	Albophoma yamanashiensis.
Summary	Terpendole C is an indole-diterpenoid mycotoxin that potently inhibits ACAT.
Details	Terpendole C is an indole-diterpenoid secondary metabolite originally isolated from Albophoma yamanashiensis as part of a series of ACAT inhibitors termed terpendoles. Among the terpendole analogues, terpendole C displayed the most potent inhibition of acyl-CoA:cholesterol acyltransferase (ACAT) with an IC50 value of 2.1 µM in vitro, implicating suppression of cholesterol esterification. Subsequent studies of related indole diterpenes demonstrated tremorgenic activity in mouse models, with terpendole C inducing significant neurotoxic signs. Additional isolation from nematophagous and endophytic fungi confirmed its occurrence across fungal taxa. These findings define terpendole C as a bioactive indole-diterpenoid combining lipid-metabolism inhibition with tremorgenic neurotoxicity.
Browse Related	Mechanism ACAT inhibitor Open full index Primary Target Acyl-CoA:cholesterol acyltransferase (ACAT) Open full index Pathway Cholesterol esterification pathway Open full index Chemical Class Indole-diterpenoid alkaloid Open full index
Mechanism	ACAT inhibitor
Primary Target	Acyl-CoA:cholesterol acyltransferase (ACAT)
Pathway	Cholesterol esterification pathway
Chemical Class	Indole-diterpenoid alkaloid
Discovery Year	1995
Keywords	indole-diterpene alkaloid sterol o-acyltransferase (acat) inhibitor cholesterol esterification inhibitor tremorgenic mycotoxin fungal metabolite neurotoxicity research compound
References	Tomoda et al., J Antibiot, 1995 (terpendoles A–D; ACAT inhibition; IC50 values) DOI: 10.7164/antibiotics.48.1 Gallagher et al., J Agric Food Chem, 1998 (terpendole M; structure-activity; tremorgenicity comparison) DOI: 10.1021/jf980767z Guo et al., Microorganisms, 2022 (isolation from Harposporium; nematicidal evaluation) DOI: 10.3390/microorganisms10081553 Pearce et al., J Nat Prod, 2018 (tremorgenic indole diterpenes including terpendole C; mouse assay) DOI: 10.1021/acs.jnatprod.8b00257
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Terpendole C (CAS: 156967-65-6)