Name: Harzianum A
Brand: Biolinks K.K.
SKU: BLK-0980
Price: 140.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Harzianum A (CAS: 156250-74-7) Product ID: BLK-0980 CAS 156250-74-7 Mechanism Protein synthesis inhibitor Primary Target Eukaryotic 60S ribosomal peptidyl transferase center Pathway Eukaryotic translation pathway
Structure	View full structure page Chemical structure of Harzianum A (CAS 156250-74-7)
CAS	156250-74-7
Molecular Formula	C23H28O6
Molecular Weight	400.47
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Harzianum A. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Harzianum A.
Source Organism	Trichoderma sp.
Summary	Harzianum A is a Trichoderma-derived trichothecene that inhibits eukaryotic translation.
Details	Harzianum A is a trichothecene-type sesquiterpene produced by Trichoderma arundinaceum and related species. It consists of the 12,13-epoxytrichothec-9-ene core structure bearing a distinctive polyketide-derived octa-2,4,6-trienedioyl substituent esterified at C4. Biosynthetic studies identified the cytochrome P450 monooxygenase Tri23 as essential for formation of the acyl side chain. As a member of the trichothecene family, harzianum A inhibits eukaryotic protein synthesis by targeting the ribosomal peptidyl transferase center, a conserved mechanism characteristic of trichothecene toxins.
Browse Related	Mechanism Protein synthesis inhibitor Open full index Primary Target Eukaryotic 60S ribosomal peptidyl transferase center Open full index Pathway Eukaryotic translation pathway Open full index Chemical Class Trichothecene sesquiterpene Open full index
Mechanism	Protein synthesis inhibitor
Primary Target	Eukaryotic 60S ribosomal peptidyl transferase center
Pathway	Eukaryotic translation pathway
Chemical Class	Trichothecene sesquiterpene
Discovery Year	2019
Keywords	protein synthesis inhibitor ribosomal inhibitor trichothecene toxin sesquiterpene mycotoxin trichoderma metabolite translation research tool
References	Proctor et al., Appl Microbiol Biotechnol, 2019 DOI: 10.1007/s00253-019-10047-2
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Harzianum A (CAS: 156250-74-7)