Name: Zelkovamycin
Brand: Biolinks K.K.
SKU: BLK-0970
Price: 180.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Zelkovamycin (CAS: 221197-33-7) Product ID: BLK-0970 CAS 221197-33-7 Mechanism Oxidative phosphorylation inhibitor Primary Target Oxidative phosphorylation complexes (OXPHOS system) Pathway Mitochondrial respiration; Energy metabolism pathway
Structure	View full structure page Chemical structure of Zelkovamycin (CAS 221197-33-7)
CAS	221197-33-7
Molecular Formula	C36H45N9O9S
Molecular Weight	779.87
Price	1mg: USD 180.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Zelkovamycin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Zelkovamycin.
Source Organism	Streptomyces sp.
Summary	Zelkovamycin is a cyclic octapeptide antibiotic that inhibits oxidative phosphorylation.
Details	Zelkovamycin is a cyclic octapeptide antibiotic isolated from Streptomyces sp. K96-0670 and structurally characterized as a thiazole- and tryptophan-containing macrocycle. Subsequent total synthesis and structural revision established zelkovamycin as a member of the argyrin natural product family. Biological investigations demonstrated that zelkovamycin uniquely inhibits oxidative phosphorylation (OXPHOS), distinguishing it from other argyrins and positioning it as a chemical probe for mitochondrial respiration. In addition to OXPHOS inhibition, zelkovamycin exhibits antibacterial activity against plant and Gram-positive pathogens and has inspired analogue synthesis for anticancer evaluation. These findings define zelkovamycin as an OXPHOS-inhibitory cyclic peptide natural product within the argyrin family.
Browse Related	Mechanism Oxidative phosphorylation inhibitor Open full index Primary Target Oxidative phosphorylation complexes (OXPHOS system) Open full index Pathway Mitochondrial respiration; Energy metabolism pathway Open full index Chemical Class Cyclic octapeptide (argyrin family) Open full index
Mechanism	Oxidative phosphorylation inhibitor
Primary Target	Oxidative phosphorylation complexes (OXPHOS system)
Pathway	Mitochondrial respiration; Energy metabolism pathway
Chemical Class	Cyclic octapeptide (argyrin family)
Discovery Year	1999
Keywords	cyclic octapeptide antibiotic argyrin family peptide oxidative phosphorylation inhibitor mitochondrial respiration inhibitor streptomyces metabolite antibacterial compound natural product research tool
References	Omura et al., J Antibiot, 1999 (production, isolation and biological properties) DOI: 10.7164/antibiotics.52.29 Omura et al., J Antibiot, 1999 (structure elucidation by NMR) DOI: 10.7164/antibiotics.52.34 Bräse et al., Chem Eur J, 2020 (total synthesis; structural revision; OXPHOS inhibition; argyrin family) DOI: 10.1002/chem.202001577 Zhang et al., Molecules, 2024 (synthesis of zelkovamycin analogues; anticancer assessment) DOI: 10.3390/molecules29184483
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Zelkovamycin (CAS: 221197-33-7)