Name: Sclerotiorin
Brand: Biolinks K.K.
SKU: BLK-0840
Price: 150.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Sclerotiorin (CAS: 549-23-5) Product ID: BLK-0840 CAS 549-23-5 Mechanism PknG inhibitor Primary Target Mycobacterium tuberculosis PknG; Amyloid beta (Aβ42) Pathway Protein phosphorylation signaling; Amyloid aggregation pathway
Structure	View full structure page Chemical structure of Sclerotiorin (CAS 549-23-5)
CAS	549-23-5
Molecular Formula	C21H23ClO5
Molecular Weight	390.86
Price	1mg: USD 150.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Sclerotiorin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Sclerotiorin.
Source Organism	Penicillium sp.
Summary	Sclerotiorin is a chlorinated azaphilone that inhibits Mycobacterium tuberculosis PknG.
Details	Sclerotiorin is a chlorinated azaphilone first reported from Penicillium sclerotiorum in 1940. Biochemical studies demonstrated that sclerotiorin noncompetitively inhibits the eukaryotic-like Ser/Thr protein kinase PknG from Mycobacterium tuberculosis (IC50 = 76.5 µM; KD = 11.4 µM), impairing intracellular mycobacterial survival in macrophages and enhancing rifampicin efficacy without host cytotoxicity. Independently, sclerotiorin delays both seeded and unseeded Aβ42 fibrillogenesis by kinetically stabilizing small oligomers with low β-sheet content, resulting in reduced seeding activity and low cellular toxicity. These mechanistic findings establish sclerotiorin as a multifunctional azaphilone scaffold targeting bacterial virulence signaling and pathological amyloid assembly.
Browse Related	Mechanism PknG inhibitor Open full index Primary Target Mycobacterium tuberculosis PknG; Amyloid beta (Aβ42) Open full index Pathway Protein phosphorylation signaling; Amyloid aggregation pathway Open full index Chemical Class Chlorinated azaphilone Open full index
Mechanism	PknG inhibitor
Primary Target	Mycobacterium tuberculosis PknG; Amyloid beta (Aβ42)
Pathway	Protein phosphorylation signaling; Amyloid aggregation pathway
Chemical Class	Chlorinated azaphilone
Discovery Year	1940
Keywords	azaphilone natural product pkng inhibitor mycobacterium tuberculosis kinase inhibitor amyloid aggregation modulator chlorinated fungal metabolite anti-tuberculosis research lead
References	MacCurtin & Reilly, Nature, 1940 (first report of sclerotiorine) DOI: 10.1038/146335b0 Chen et al., Tuberculosis (Edinb), 2017 (PknG non-competitive inhibition; macrophage infection model) DOI: 10.1016/j.tube.2017.01.001 Kreutzer et al., J Mol Biol, 2020 (Aβ42 oligomer stabilization; delayed fibrillogenesis) DOI: 10.1016/j.jmb.2020.01.033 Chen et al., J Nat Prod, 2015 (sclerotiorin-type azaphilones structural class) DOI: 10.1021/acs.jnatprod.5c00169 Tanaka et al., J Antibiot, 1995 (isochromophilones; related azaphilones and gp120-CD4 screening context) DOI: 10.7164/antibiotics.48.703
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Sclerotiorin (CAS: 549-23-5)