Name: Altenusin
Brand: Biolinks K.K.
SKU: BLK-0810
Price: 120.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Altenusin (CAS: 31186-12-6) Product ID: BLK-0810 CAS 31186-12-6 Mechanism Multi-target enzyme inhibitor Primary Target Protein tyrosine phosphatase 1B (PTP1B); Myosin light chain kinase (MLCK); Trypanothione reductase Pathway Insulin signaling pathway; NF-κB signaling pathway; Redox metabolism
Structure	View full structure page Chemical structure of Altenusin (CAS 31186-12-6)
CAS	31186-12-6
Molecular Formula	C15H14O6
Molecular Weight	290.27
Price	1mg: USD 120.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	3,3'-Dimethyl-4,4?-dihydroxy-5,5'-diphenyl ether
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Data	1H NMR (CD3OD, 500 MHz) [View] [Full page] 13C NMR (CD3OD, 125 MHz) [View] [Full page]
NMR Spectral Data	Representative 1H NMR (CD3OD, 500 MHz) spectrum confirming the structure of Altenusin. Representative 13C NMR (CD3OD, 125 MHz) spectrum supporting structural assignment of Altenusin.
Source Organism	Penicillium sp.
Summary	Altenusin is a fungal biphenyl metabolite that inhibits MLCK, PTP1B, and trypanothione reductase and is used in metabolic and antiparasitic research.
Details	Altenusin is a fungal-derived biphenyl metabolite originally isolated as an inhibitor of myosin light chain kinase from microbial sources. Subsequent studies demonstrated its inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a regulator of insulin and inflammatory signaling pathways, supporting its potential metabolic and anti-inflammatory relevance. Altenusin also inhibits trypanothione reductase from Trypanosoma cruzi, a key enzyme in parasite redox metabolism, suggesting antiparasitic potential. Collectively, these findings establish altenusin as a multifunctional natural product enzyme inhibitor targeting phosphorylation-dependent signaling and redox regulatory systems.
Browse Related	Mechanism Multi-target enzyme inhibitor Open full index Primary Target Protein tyrosine phosphatase 1B (PTP1B); Myosin light chain kinase (MLCK); Trypanothione reductase Open full index Pathway Insulin signaling pathway; NF-κB signaling pathway; Redox metabolism Open full index Chemical Class Biphenyl polyketide Open full index
Mechanism	Multi-target enzyme inhibitor
Primary Target	Protein tyrosine phosphatase 1B (PTP1B); Myosin light chain kinase (MLCK); Trypanothione reductase
Pathway	Insulin signaling pathway; NF-κB signaling pathway; Redox metabolism
Chemical Class	Biphenyl polyketide
Discovery Year	1995
Keywords	mlck inhibitor ptp1b inhibitor trypanothione reductase inhibitor phosphorylation signaling modulator redox metabolism regulator biphenyl natural product alternaria metabolite anti-inflammatory research compound
References	Matsumoto T et al., Biosci Biotechnol Biochem, 1995, 59:1333-1335 DOI: 10.1271/bbb.59.1333 Kwon HC et al., FEMS Microbiol Lett, 2008, 287:121-126 DOI: 10.1111/j.1574-6968.2008.01221.x Yamamoto K et al., Biol Pharm Bull, 2021, 44:363-369 DOI: 10.1248/bpb.b20-00994
Request pricing, availability, or bulk supply information for this compound. Get a Quote General Inquiry
Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
← Back to Catalog
Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.
Representative NMR Data 1H NMR (CD3OD, 500 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 13C NMR (CD3OD, 125 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 1H NMR (CD3OD, 500 MHz) 13C NMR (CD3OD, 125 MHz) Representative spectral data. Actual batch data may vary.

Altenusin (CAS: 31186-12-6)