Name: Cyclopenin
Brand: Biolinks K.K.
SKU: BLK-0770
Price: 170.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Cyclopenin (CAS: 19553-26-5) Product ID: BLK-0770 CAS 19553-26-5 Mechanism NF-κB inhibitor Primary Target SARS-CoV-2 main protease (Mpro); NF-κB signaling components Pathway Viral polyprotein processing; NF-κB signaling pathway
Structure	View full structure page Chemical structure of Cyclopenin (CAS 19553-26-5)
CAS	19553-26-5
Molecular Formula	C17H14N2O3
Molecular Weight	294.31
Price	1mg: USD 170.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Cyclopenin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Cyclopenin.
Source Organism	Penicillium sp.
Summary	Cyclopenin is a benzodiazepine alkaloid that inhibits NF-κB signaling and SARS-CoV-2 Mpro.
Details	Cyclopenin is a benzodiazepine alkaloid produced by Penicillium and Aspergillus species and belongs to the cyclopenin-cyclopenol metabolite family. Recent studies demonstrate that cyclopenin inhibits SARS-CoV-2 main protease (Mpro) in vitro at submicromolar concentrations and suppresses LPS-induced NF-κB activation, reducing nitric oxide and pro-inflammatory cytokine production. In cellular models, it downregulates iNOS, IL-1β, and IL-6 expression and ameliorates inflammation-associated phenotypes. Cyclopenin thus functions as a dual anti-inflammatory and antiviral scaffold with value in chemical biology and drug discovery research.
Browse Related	Mechanism NF-κB inhibitor Open full index Primary Target SARS-CoV-2 main protease (Mpro); NF-κB signaling components Open full index Pathway Viral polyprotein processing; NF-κB signaling pathway Open full index Chemical Class Benzodiazepine alkaloid Open full index
Mechanism	NF-κB inhibitor
Primary Target	SARS-CoV-2 main protease (Mpro); NF-κB signaling components
Pathway	Viral polyprotein processing; NF-κB signaling pathway
Chemical Class	Benzodiazepine alkaloid
Discovery Year	1976
Keywords	sars-cov-2 mpro inhibitor nf-κb pathway inhibitor anti-inflammatory compound nitric oxide production suppressor benzodiazepine alkaloid penicillium metabolite antiviral research scaffold
References	Anke et al., J Basic Microbiol, 1984 DOI: 10.1002/jobm.3630240908 Elissawy et al., Biomolecules, 2021 DOI: 10.3390/biom11091366 Chen et al., Pharmacol Res, 2020 DOI: 10.1038/s41429-020-0302-9
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Cyclopenin (CAS: 19553-26-5)