Name: Fuscin
Brand: Biolinks K.K.
SKU: BLK-0760
Price: 150.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Fuscin (CAS: 83-85-2) Product ID: BLK-0760 CAS 83-85-2 Mechanism CCR5 antagonist Primary Target CCR5; SarA; AgrA Pathway HIV entry pathway; Biofilm regulation
Structure	View full structure page Chemical structure of Fuscin (CAS 83-85-2)
CAS	83-85-2
Molecular Formula	C15H16O5
Molecular Weight	276.29
Price	1mg: USD 150.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Fuscin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Fuscin.
Source Organism	Oidiodendron sp.
Summary	Fuscin is a fungal polyketide that antagonizes CCR5 and inhibits MRSA growth and biofilm formation.
Details	Fuscin is a polyketide metabolite isolated from Oidiodendron griseum. It competes with macrophage inflammatory protein-1β for binding to the human CCR5 receptor, a key co-receptor involved in HIV-1 entry, thereby functioning as a CCR5 antagonist. Fuscin and related derivatives also display antibacterial and antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA), with docking studies suggesting interaction with biofilm regulatory proteins such as SarA and AgrA. These properties position fuscin as a dual-function research tool for studying viral entry mechanisms and bacterial virulence regulation.
Browse Related	Mechanism CCR5 antagonist Open full index Primary Target CCR5; SarA; AgrA Open full index Pathway HIV entry pathway; Biofilm regulation Open full index Chemical Class Polyketide Open full index
Mechanism	CCR5 antagonist
Primary Target	CCR5; SarA; AgrA
Pathway	HIV entry pathway; Biofilm regulation
Chemical Class	Polyketide
Discovery Year	2003
Keywords	ccr5 antagonist hiv entry inhibitor antibiofilm agent gram-positive bacteria inhibitor polyketide metabolite fungal secondary metabolite infection research tool
References	Tsunakawa et al., J Nat Prod, 2003 DOI: 10.1021/np030146m González et al., J Enzyme Inhib Med Chem, 2023 DOI: 10.1080/08927014.2023.2276926 Debitus et al., Mar Drugs, 2017 DOI: 10.3390/md15040111
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Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Fuscin (CAS: 83-85-2)