Name: Cyclopenol
Brand: Biolinks K.K.
SKU: BLK-0750
Price: 170.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Cyclopenol (CAS: 20007-85-6) Product ID: BLK-0750 CAS 20007-85-6 Mechanism NF-κB pathway inhibitor Primary Target NF-κB signaling components Pathway NF-κB signaling pathway; Cytokine regulation
Structure	View full structure page Chemical structure of Cyclopenol (CAS 20007-85-6)
CAS	20007-85-6
Molecular Formula	C17H14N2O4
Molecular Weight	310.31
Price	1mg: USD 170.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Cyclopenol. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Cyclopenol.
Source Organism	Penicillium sp.
Summary	Cyclopenol is a benzodiazepine alkaloid that suppresses NF-κB–mediated inflammatory signaling.
Details	Cyclopenol is a benzodiazepine-type alkaloid produced by Penicillium species, including marine and mangrove-derived strains. It has been shown to inhibit LPS-induced nitric oxide production and suppress IL-6 and iNOS expression through inhibition of upstream NF-κB activation. Structural studies reveal a 2,5-dioxopiperazine-related scaffold typical of cyclopenin-cyclopenol metabolites. Cyclopenol is used as a chemical probe to study inflammatory signaling and fungal benzodiazepine biosynthesis.
Browse Related	Mechanism NF-κB pathway inhibitor Open full index Primary Target NF-κB signaling components Open full index Pathway NF-κB signaling pathway; Cytokine regulation Open full index Chemical Class Benzodiazepine alkaloid Open full index
Mechanism	NF-κB pathway inhibitor
Primary Target	NF-κB signaling components
Pathway	NF-κB signaling pathway; Cytokine regulation
Chemical Class	Benzodiazepine alkaloid
Discovery Year	1976
Keywords	nf-κb inhibitor anti-inflammatory compound nitric oxide synthase inhibitor benzodiazepine alkaloid 5-dioxopiperazine scaffold penicillium metabolite natural product research tool
References	Anke et al., J Basic Microbiol, 1984 DOI: 10.1002/jobm.3630240908 Zhang et al., Nat Prod Res, 2014 DOI: 10.1080/10286020.2014.911290 Abdel-Lateff et al., Z Naturforsch C, 2021 DOI: 10.1515/znc-2021-0236
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Cyclopenol (CAS: 20007-85-6)