Name: Palitantin
Brand: Biolinks K.K.
SKU: BLK-0740
Price: 140.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Palitantin (CAS: 15265-28-8) Product ID: BLK-0740 CAS 15265-28-8 Mechanism PTP1B inhibitor Primary Target Protein tyrosine phosphatase 1B (PTP1B) Pathway Insulin signaling pathway
Structure	View full structure page Chemical structure of Palitantin (CAS 15265-28-8)
CAS	15265-28-8
Molecular Formula	C14H22O4
Molecular Weight	254.32
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Palitantin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Palitantin.
Source Organism	Penicillium sp.
Summary	Palitantin is a fungal polyketide secondary metabolite with reported PTP1B inhibitory activity.
Details	Palitantin is a fungal-derived polyketide originally reported from Penicillium species and later isolated from Antarctic fungi such as Geomyces sp. Structurally characterized by a cyclohexenone-containing framework, palitantin has been investigated for its ecological antifungal role and more recently for its biological activity as a protein tyrosine phosphatase 1B (PTP1B) inhibitor. Derivatives of palitantin have shown moderate antiplasmodial and antibacterial activities, while the parent compound displays measurable PTP1B inhibitory activity (IC50 ~7-8 µM). Its synthetic accessibility via organocatalytic Robinson annulation has further enabled stereoselective total synthesis and derivatization studies.
Browse Related	Mechanism PTP1B inhibitor Open full index Primary Target Protein tyrosine phosphatase 1B (PTP1B) Open full index Pathway Insulin signaling pathway Open full index Chemical Class Cyclohexenone polyketide Open full index
Mechanism	PTP1B inhibitor
Primary Target	Protein tyrosine phosphatase 1B (PTP1B)
Pathway	Insulin signaling pathway
Chemical Class	Cyclohexenone polyketide
Discovery Year	1997
Keywords	ptp1b inhibitor polyketide natural product fungal metabolite antifungal compound metabolic disease research scaffold
References	Frisvad et al., Antonie Van Leeuwenhoek, 1997 DOI: 10.1023/a:1000244502608 Li et al., Nat Prod Res, 2021 DOI: 10.1080/10286020.2021.1915995 Campos et al., Fitoterapia, 2024 DOI: 10.1016/j.fitote.2024.106310 Hayashi et al., J Org Chem, 2007 DOI: 10.1021/jo701477v Sato et al., J Chem Ecol, 2006 DOI: 10.1007/s10886-005-3545-9
Request pricing, availability, or bulk supply information for this compound. Get a Quote General Inquiry
Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
← Back to Catalog
Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Palitantin (CAS: 15265-28-8)