Name: Andrastin A
Brand: Biolinks K.K.
SKU: BLK-0720
Price: 190.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Andrastin A (CAS: 174232-42-9) Product ID: BLK-0720 CAS 174232-42-9 Mechanism Farnesyltransferase inhibitor Primary Target Protein farnesyltransferase (FTase) Pathway Ras prenylation pathway; CAAX protein processing
Structure	View full structure page Chemical structure of Andrastin A (CAS 174232-42-9)
CAS	174232-42-9
Molecular Formula	C28H38O7
Molecular Weight	486.61
Price	1mg: USD 190.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Andrastin A. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Andrastin A.
Source Organism	Penicillium sp.
Summary	Andrastin A is a fungal meroterpenoid that inhibits protein farnesyltransferase and is used in Ras prenylation research.
Details	Andrastin A is a meroterpenoid secondary metabolite isolated from the cultured broth of Penicillium sp. FO-3929. It was identified as a protein farnesyltransferase (FTase) inhibitor with an IC50 value of 24.9 µM. FTase catalyzes the prenylation of Ras and other CAAX motif-containing proteins, a post-translational modification required for membrane localization and oncogenic signaling. By inhibiting FTase, andrastin A interferes with Ras-dependent signaling pathways implicated in tumor development, positioning it as a natural product lead compound for anticancer research.
Browse Related	Mechanism Farnesyltransferase inhibitor Open full index Primary Target Protein farnesyltransferase (FTase) Open full index Pathway Ras prenylation pathway; CAAX protein processing Open full index Chemical Class Meroterpenoid (PKS–terpene hybrid) Open full index
Mechanism	Farnesyltransferase inhibitor
Primary Target	Protein farnesyltransferase (FTase)
Pathway	Ras prenylation pathway; CAAX protein processing
Chemical Class	Meroterpenoid (PKS–terpene hybrid)
Discovery Year	1996
Keywords	protein farnesyltransferase inhibitor ras prenylation inhibitor oncogenic ras signaling modulator meroterpenoid natural product penicillium metabolite anticancer research compound
References	Omura S et al., J Antibiot (Tokyo), 1996, 49:414-417 DOI: 10.7164/antibiotics.49.414 Fernandez-Bodega MA et al., Front Microbiol, 2017, 8:813 DOI: 10.3389/fmicb.2017.00813 Bridge PD et al., Mycol Res, 2005, 109:1117-1124 DOI: 10.1017/S0953756205003734
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Andrastin A (CAS: 174232-42-9)