Name: Streptochlorin
Brand: Biolinks K.K.
SKU: BLK-0710
Price: 210.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Streptochlorin (CAS: 120191-51-7) Product ID: BLK-0710 CAS 120191-51-7 Mechanism Leucyl-tRNA synthetase inhibitor Primary Target Leucyl-tRNA synthetase (LeuRS) Pathway Protein translation pathway; Aminoacyl-tRNA biosynthesis
Structure	View full structure page Chemical structure of Streptochlorin (CAS 120191-51-7)
CAS	120191-51-7
Molecular Formula	C11H7ClN2O
Molecular Weight	218.64
Price	1mg: USD 210.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Streptochlorin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Streptochlorin.
Source Organism	Streptomyces roseolilacinus.
Summary	Streptochlorin is a marine indole alkaloid with antifungal activity and predicted LeuRS inhibition.
Details	Streptochlorin is an indole alkaloid isolated from marine Streptomyces species and identified as a bioactive lead compound against phytopathogenic fungi. Structure-activity relationship studies and molecular docking analyses demonstrated that streptochlorin and its synthetic analogues bind to leucyl-tRNA synthetase (LeuRS) in a manner comparable to known LeuRS inhibitors, supporting inhibition of aminoacyl-tRNA synthesis as a plausible mechanism underlying antifungal activity. Several derivatives displayed superior growth inhibition against Alternaria leaf spot, Gibberella zeae, and Rhizoctonia solani, with EC50 values outperforming commercial fungicides. These findings position streptochlorin as a marine-derived indole scaffold for antifungal development targeting translational machinery.
Browse Related	Mechanism Leucyl-tRNA synthetase inhibitor Open full index Primary Target Leucyl-tRNA synthetase (LeuRS) Open full index Pathway Protein translation pathway; Aminoacyl-tRNA biosynthesis Open full index Chemical Class Indole alkaloid Open full index
Mechanism	Leucyl-tRNA synthetase inhibitor
Primary Target	Leucyl-tRNA synthetase (LeuRS)
Pathway	Protein translation pathway; Aminoacyl-tRNA biosynthesis
Chemical Class	Indole alkaloid
Discovery Year	2004
Keywords	indole alkaloid leucyl-trna synthetase (leurs) inhibitor antifungal agent marine streptomyces metabolite oxazole scaffold phytopathogen inhibitor natural product research tool
References	Wang et al., Mar Drugs, 2022 (pimprinine and streptochlorin derivatives; LeuRS docking) DOI: 10.3390/md20120740 Zhang et al., Bioorg Med Chem, 2021 (imidazole analogues; antifungal; LeuRS docking) DOI: 10.1016/j.bmc.2021.116073 Li et al., J Agric Food Chem, 2023 (benzoxaborole derivatives; LeuRS docking; EC50) DOI: 10.1021/acs.jafc.2c08053
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Streptochlorin (CAS: 120191-51-7)