Name: Pyranonigrin A
Brand: Biolinks K.K.
SKU: BLK-0700
Price: 180.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Pyranonigrin A (CAS: 773855-65-5) Product ID: BLK-0700 CAS 773855-65-5 Mechanism Antioxidant Primary Target Reactive oxygen species (ROS) Pathway Oxidative stress response
Structure	View full structure page Chemical structure of Pyranonigrin A (CAS 773855-65-5)
CAS	773855-65-5
Molecular Formula	C10H9NO5
Molecular Weight	223.18
Price	1mg: USD 180.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Pyranonigrin A. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Pyranonigrin A.
Source Organism	Aspergillus sp.
Summary	Pyranonigrin A is a fungal antioxidant metabolite with UV-protective and ROS-scavenging activity.
Details	Pyranonigrin A is a tetramic acid-derived fungal secondary metabolite produced by Aspergillus niger and related species. Its structure was reassigned based on spectroscopic and computational analysis, confirming a fused γ-pyrone-pyrrole core with defined absolute configuration. Biologically, pyranonigrin A exhibits antioxidant activity comparable to ferulic acid and contributes to UV resistance in fungal isolates, including strains recovered from the International Space Station. Biosynthetic studies have elucidated its gene cluster and key enzymatic steps responsible for γ-pyrone formation and exo-methylene installation. Computational analyses further suggest potential inhibitory interactions with SARS-CoV-2 main protease (Mpro), expanding its relevance to antiviral screening research.
Browse Related	Mechanism Antioxidant Open full index Primary Target Reactive oxygen species (ROS) Open full index Pathway Oxidative stress response Open full index Chemical Class Tetramic acid derivative Open full index
Mechanism	Antioxidant
Primary Target	Reactive oxygen species (ROS)
Pathway	Oxidative stress response
Chemical Class	Tetramic acid derivative
Discovery Year	2007
Keywords	antioxidant metabolite ros scavenger uv-protective compound tetramic acid derivative aspergillus niger metabolite oxidative stress research tool
References	Wang et al., J Nat Prod, 2007 DOI: 10.1021/np070175n Bakare et al., Biophys Chem, 2020 DOI: 10.1016/j.bpc.2020.106425 Blachowicz et al., Front Microbiol, 2020 DOI: 10.3389/fmicb.2020.00931 Takeda et al., Biosci Biotechnol Biochem, 2007 DOI: 10.1271/bbb.70310 Chiang et al., Org Lett, 2015 DOI: 10.1021/acs.orglett.5b02435
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Pyranonigrin A (CAS: 773855-65-5)