Name: Funalenone
Brand: Biolinks K.K.
SKU: BLK-0690
Price: 190.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Funalenone (CAS: 259728-61-5) Product ID: BLK-0690 CAS 259728-61-5 Mechanism HIV-1 integrase inhibitor Primary Target HIV-1 integrase; Matrix metalloproteinase-1 (MMP-1) Pathway Viral integration pathway; Extracellular matrix remodeling
Structure	View full structure page Chemical structure of Funalenone (CAS 259728-61-5)
CAS	259728-61-5
Molecular Formula	C15H12O6
Molecular Weight	288.25
Price	1mg: USD 190.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Funalenone. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Funalenone.
Source Organism	Aspergillus sp.
Summary	Funalenone is a fungal phenalenone that inhibits HIV-1 integrase and type I collagenase (MMP-1).
Details	Funalenone is a phenalenone secondary metabolite originally isolated from Aspergillus niger. It inhibits type I collagenase (MMP-1) and displays selective inhibition of HIV-1 integrase with micromolar potency, leading to suppression of viral replication in vitro. The compound shows greater activity against MMP-1 than against type IV collagenases and demonstrates favorable selectivity in antiviral assays. As a dual integrase and metalloproteinase inhibitor, funalenone represents a valuable phenalenone scaffold for antiviral and matrix biology research.
Browse Related	Mechanism HIV-1 integrase inhibitor Open full index Primary Target HIV-1 integrase; Matrix metalloproteinase-1 (MMP-1) Open full index Pathway Viral integration pathway; Extracellular matrix remodeling Open full index Chemical Class Phenalenone polyketide Open full index
Mechanism	HIV-1 integrase inhibitor
Primary Target	HIV-1 integrase; Matrix metalloproteinase-1 (MMP-1)
Pathway	Viral integration pathway; Extracellular matrix remodeling
Chemical Class	Phenalenone polyketide
Discovery Year	1999
Keywords	hiv-1 integrase inhibitor mmp-1 inhibitor collagenase inhibitor phenalenone natural product aspergillus metabolite antiviral research scaffold
References	Umezawa et al., J Antibiot, 1999 DOI: 10.7164/antibiotics.52.1095 Oh et al., J Antibiot, 2005 DOI: 10.1038/ja.2005.8
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Funalenone (CAS: 259728-61-5)