Name: Nocardamine
Brand: Biolinks K.K.
SKU: BLK-0680
Price: 100.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Nocardamine (CAS: 26605-16-3) Product ID: BLK-0680 CAS 26605-16-3 Mechanism Iron chelator Primary Target Ferric iron (Fe3+) Pathway Iron acquisition pathway; Siderophore transport
Structure	View full structure page Chemical structure of Nocardamine (CAS 26605-16-3)
CAS	26605-16-3
Molecular Formula	C27H48N6O9
Molecular Weight	600.71
Price	1mg: USD 100.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	Desferrioxamine E
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Nocardamine. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Nocardamine.
Source Organism	Streptomyces sp.
Summary	Nocardamine is a cyclic hydroxamate siderophore that chelates Fe3+ in iron metabolism studies.
Details	Nocardamine, also known as desferrioxamine E, is a cyclic trihydroxamate siderophore produced by Streptomyces species that binds ferric iron (Fe3+) with extremely high affinity. By forming a stable hexadentate Fe3+ complex, it mediates iron uptake in bacteria via specific outer membrane transporters such as FoxA and can also deprive pathogens of iron under limiting conditions. Nocardamine exhibits antimalarial activity through iron chelation-mediated growth inhibition and has been used as a probe to study siderophore-dependent transport systems. Its strong and selective Fe3+ binding makes it a valuable research tool for dissecting iron acquisition, microbial competition, and iron-dependent metabolic pathways.
Browse Related	Mechanism Iron chelator Open full index Primary Target Ferric iron (Fe3+) Open full index Pathway Iron acquisition pathway; Siderophore transport Open full index Chemical Class Cyclic trihydroxamate siderophore Open full index
Mechanism	Iron chelator
Primary Target	Ferric iron (Fe3+)
Pathway	Iron acquisition pathway; Siderophore transport
Chemical Class	Cyclic trihydroxamate siderophore
Discovery Year	1976
Keywords	siderophore iron chelator fe3+ chelation compound hydroxamate metabolite foxa transporter ligand antimalarial iron depletion research tool
References	DeBoer et al., J Antibiot, 1976 DOI: 10.7164/antibiotics.29.1182 Lamont et al., ACS Chem Biol, 2020 DOI: 10.1021/acschembio.0c00535 Ong et al., Molecules, 2022 DOI: 10.3390/molecules27072292 Liu et al., npj Biofilms Microbiomes, 2024 DOI: 10.1038/s41429-024-00763-x
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Nocardamine (CAS: 26605-16-3)