Name: Harzianopyridone
Brand: Biolinks K.K.
SKU: BLK-0670
Price: 200.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Harzianopyridone (CAS: 126637-69-2) Product ID: BLK-0670 CAS 126637-69-2 Mechanism Complex II inhibitor Primary Target Succinate dehydrogenase (Complex II); Zika virus RNA-dependent RNA polymerase Pathway Mitochondrial respiratory chain inhibition; Viral RNA polymerase pathway
Structure	View full structure page Chemical structure of Harzianopyridone (CAS 126637-69-2)
CAS	126637-69-2
Molecular Formula	C14H19NO5
Molecular Weight	281.31
Price	1mg: USD 200.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Harzianopyridone. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Harzianopyridone.
Source Organism	Trichoderma harzianum.
Summary	Harzianopyridone is a fungal pyridone natural product that inhibits mitochondrial complex II and Zika virus replication.
Details	Harzianopyridone is a pentasubstituted pyridone natural product produced by Trichoderma harzianum and related fungi. Biosynthetic studies revealed an iterative pathway involving methyltransferase and flavin-dependent monooxygenase enzymes closely related to the atpenin biosynthetic system. Harzianopyridone functions as a potent inhibitor of mitochondrial complex II (succinate dehydrogenase), thereby interfering with the respiratory chain. In addition, it has been reported to inhibit Zika virus replication by directly binding to and suppressing RNA-dependent RNA polymerase (RdRp) activity. These findings indicate that harzianopyridone possesses dual bioactivity targeting both mitochondrial respiration and viral RNA synthesis.
Browse Related	Mechanism Complex II inhibitor Open full index Primary Target Succinate dehydrogenase (Complex II); Zika virus RNA-dependent RNA polymerase Open full index Pathway Mitochondrial respiratory chain inhibition; Viral RNA polymerase pathway Open full index Chemical Class Pyridone alkaloid Open full index
Mechanism	Complex II inhibitor
Primary Target	Succinate dehydrogenase (Complex II); Zika virus RNA-dependent RNA polymerase
Pathway	Mitochondrial respiratory chain inhibition; Viral RNA polymerase pathway
Chemical Class	Pyridone alkaloid
Discovery Year	2009
Keywords	mitochondrial complex ii inhibitor succinate dehydrogenase inhibitor antiviral activity against zika virus pyridone natural product trichoderma metabolite respiratory chain inhibitor antiviral research compound
References	Vinale et al., Lett Appl Microbiol, 2009 DOI: 10.1111/j.1472-765X.2009.02599.x Yan et al., J Am Chem Soc, 2020 DOI: 10.1021/jacs.0c03438 Zhang et al., Molecules, 2024 DOI: 10.3390/molecules29050978
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Harzianopyridone (CAS: 126637-69-2)