Name: NG 012
Brand: Biolinks K.K.
SKU: BLK-0650
Price: 90.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

NG 012 (CAS: 141731-76-2) Product ID: BLK-0650 CAS 141731-76-2 Mechanism Neuronal differentiation enhancer Primary Target Not identified (NGF signaling enhancement) Pathway NGF–TrkA signaling pathway; Neuronal differentiation
Structure	View full structure page Chemical structure of NG 012 (CAS 141731-76-2)
CAS	141731-76-2
Molecular Formula	C32H38O15
Molecular Weight	662.65
Price	1mg: USD 90.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of NG 012. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of NG 012.
Source Organism	Penicillium sp.
Summary	NG 012 is a fungal NGF potentiator that enhances NGF-dependent neurite outgrowth.
Details	NG-012 is a secondary metabolite isolated from Penicillium verruculosum that enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Similar to NG-011, it does not mimic NGF directly but potentiates NGF-dependent signaling pathways, thereby increasing neuronal differentiation responses. Structural studies revealed that NG-012 belongs to a macrocyclic polylactone class of fungal metabolites. It serves as a neurobiology research tool to investigate NGF-TrkA signaling, neuronal differentiation mechanisms, and neurotrophic pathway modulation.
Browse Related	Mechanism Neuronal differentiation enhancer Open full index Primary Target Not identified (NGF signaling enhancement) Open full index Pathway NGF–TrkA signaling pathway; Neuronal differentiation Open full index Chemical Class Macrocyclic polylactone Open full index
Mechanism	Neuronal differentiation enhancer
Primary Target	Not identified (NGF signaling enhancement)
Pathway	NGF–TrkA signaling pathway; Neuronal differentiation
Chemical Class	Macrocyclic polylactone
Discovery Year	1992
Keywords	nerve growth factor potentiator neurite outgrowth stimulator pc12 differentiation assay tool penicillium verruculosum metabolite neurotrophic modulator
References	Kobayashi et al., J Antibiot, 1992 DOI: 10.7164/antibiotics.45.1559 Kobayashi et al., J Antibiot, 1992 DOI: 10.7164/antibiotics.45.1566
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

NG 012 (CAS: 141731-76-2)