Name: Elasnin
Brand: Biolinks K.K.
SKU: BLK-0630
Price: 120.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Elasnin (CAS: 68112-21-0) Product ID: BLK-0630 CAS 68112-21-0 Mechanism Neutrophil elastase inhibitor Primary Target Human neutrophil elastase Pathway Protease inhibition; Biofilm formation pathway
Structure	View full structure page Chemical structure of Elasnin (CAS 68112-21-0)
CAS	68112-21-0
Molecular Formula	C24H40O4
Molecular Weight	392.58
Price	1mg: USD 120.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 60–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Elasnin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Elasnin.
Source Organism	Streptomyces sp.
Summary	Elasnin is a Streptomyces-derived elastase inhibitor with potent antibiofilm activity against MRSA.
Details	Elasnin is a polyketide-derived metabolite isolated from Streptomyces noboritoensis and originally identified as a selective inhibitor of human granulocyte elastase. It inhibits human elastase at low micromolar concentrations while showing minimal activity against related serine proteases. More recently, elasnin has been shown to eradicate methicillin-resistant Staphylococcus aureus (MRSA) biofilms, including daptomycin-resistant strains, by disrupting biofilm matrix integrity and repressing cell division, cell wall synthesis, and virulence-associated pathways. Multi-omics analyses indicate interference with key regulatory systems and biofilm maintenance mechanisms, highlighting its potential as a biofilm-targeting anti-virulence agent.
Browse Related	Mechanism Neutrophil elastase inhibitor Open full index Primary Target Human neutrophil elastase Open full index Pathway Protease inhibition; Biofilm formation pathway Open full index Chemical Class Polyketide Open full index
Mechanism	Neutrophil elastase inhibitor
Primary Target	Human neutrophil elastase
Pathway	Protease inhibition; Biofilm formation pathway
Chemical Class	Polyketide
Discovery Year	1978
Keywords	human neutrophil elastase inhibitor serine protease inhibitor antibiofilm agent mrsa biofilm eradicator streptomyces metabolite anti-virulence compound infection research tool
References	Umezawa et al., J Antibiot, 1978 DOI: 10.7164/antibiotics.31.1116 Tan et al., Microbiol Spectr, 2022 DOI: 10.1128/spectrum.02320-21 Lim et al., mSystems, 2022 DOI: 10.1128/msystems.01393-21 Lim et al., Front Microbiol, 2022 DOI: 10.3389/fmicb.2022.967845
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Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 60–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Elasnin (CAS: 68112-21-0)