Name: Virustomycin A
Brand: Biolinks K.K.
SKU: BLK-0610
Price: 89.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Virustomycin A (CAS: 84777-85-5) Product ID: BLK-0610 CAS 84777-85-5 Mechanism RNA synthesis inhibitor Primary Target ATP-generating nucleotide biosynthesis enzymes Pathway Nucleic acid biosynthesis pathway
Structure	View full structure page Chemical structure of Virustomycin A (CAS 84777-85-5)
CAS	84777-85-5
Molecular Formula	C48H71NO14
Molecular Weight	886.09
Price	1mg: USD 89.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Virustomycin A. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Virustomycin A.
Source Organism	Streptomyces sp.
Summary	Virustomycin A is an 18-membered macrolide antibiotic that inhibits RNA biosynthesis.
Details	Virustomycin A (AM-2604 A) is an 18-membered macrolide antibiotic isolated from Streptomyces species. It exhibits potent in vitro inhibitory activity against various RNA and DNA viruses and shows selective antitrypanosomal activity. Mechanistic studies in Trichomonas foetus demonstrated that virustomycin A inhibits RNA, DNA, and protein biosynthesis, with the most pronounced effect on RNA synthesis. The compound interferes with nucleotide formation from uridine and adenosine without blocking nucleoside transport or directly inhibiting uridine kinase or uracil phosphoribosyltransferase, suggesting disruption of cellular phosphate-donor formation, possibly involving the ATP-generating system. Biosynthetic investigations identified a type I polyketide synthase gene cluster responsible for virustomycin A assembly. These findings define virustomycin A as a bioactive macrolide that suppresses nucleic acid biosynthesis through interference with nucleotide metabolism.
Browse Related	Mechanism RNA synthesis inhibitor Open full index Primary Target ATP-generating nucleotide biosynthesis enzymes Open full index Pathway Nucleic acid biosynthesis pathway Open full index Chemical Class 18-membered macrolide Open full index
Mechanism	RNA synthesis inhibitor
Primary Target	ATP-generating nucleotide biosynthesis enzymes
Pathway	Nucleic acid biosynthesis pathway
Chemical Class	18-membered macrolide
Discovery Year	1982
Keywords	18-membered macrolide antibiotic rna synthesis inhibitor antiviral agent antitrypanosomal compound streptomyces metabolite type i polyketide synthase product microbial natural product
References	Umezawa et al., J Antibiot, 1982 (isolation of AM-2604 A; antiviral activity) DOI: 10.7164/antibiotics.35.1632 Ito et al., J Antibiot, 1983 (mode of action; inhibition of RNA/DNA/protein synthesis in Trichomonas) DOI: 10.7164/antibiotics.36.1755 Watanabe et al., J Antibiot, 2008 (selective antitrypanosomal activity screening) DOI: 10.1038/ja.2008.52 Kikuchi et al., ChemBioChem, 2022 (virustomycin A biosynthetic gene cluster; PKS engineering) DOI: 10.1002/cbic.202200670
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Virustomycin A (CAS: 84777-85-5)