Name: Pyripyropene A
Brand: Biolinks K.K.
SKU: BLK-0570
Price: 360.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Pyripyropene A (CAS: 147444-03-9) Product ID: BLK-0570 CAS 147444-03-9 Mechanism SOAT2 inhibitor Primary Target Sterol O-acyltransferase 2 (SOAT2; ACAT2) Pathway Cholesterol esterification
Structure	View full structure page Chemical structure of Pyripyropene A (CAS 147444-03-9)
CAS	147444-03-9
Molecular Formula	C31H37NO10
Molecular Weight	583.64
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Pyripyropene A. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Pyripyropene A.
Source Organism	Aspergillus fumigatus.
Summary	Pyripyropene A is a fungal meroterpenoid that selectively inhibits sterol O-acyltransferase 2 (SOAT2/ACAT2).
Details	Pyripyropene A is a secondary metabolite produced by Aspergillus fumigatus and represents one of the most potent and selective inhibitors of sterol O-acyltransferase 2 (SOAT2), also known as ACAT2. It inhibits cholesterol esterification in microsomal assays with nanomolar potency and shows strong isozyme selectivity over SOAT1. Structure-activity relationship studies and synthetic analogue development confirmed its role as a lead compound for dyslipidemia and anti-atherosclerotic drug discovery. In addition to its lipid-metabolism activity, pyripyropene A exhibits strong insecticidal activity against aphids and other sap-sucking agricultural pests.
Browse Related	Mechanism SOAT2 inhibitor Open full index Primary Target Sterol O-acyltransferase 2 (SOAT2; ACAT2) Open full index Pathway Cholesterol esterification Open full index Chemical Class Meroterpenoid Open full index
Mechanism	SOAT2 inhibitor
Primary Target	Sterol O-acyltransferase 2 (SOAT2; ACAT2)
Pathway	Cholesterol esterification
Chemical Class	Meroterpenoid
Discovery Year	1994
Keywords	sterol o-acyltransferase 2 (soat2) inhibitor acat2 selective inhibitor cholesterol esterification inhibitor aspergillus fumigatus metabolite anti-atherosclerotic lead compound
References	Omura et al., J Antibiot, 1994 DOI: 10.7164/antibiotics.47.148 Yoshida et al., ChemMedChem, 2017 DOI: 10.1002/cmdc.201700645 Kakeya et al., J Antibiot, 2016 DOI: 10.1038/ja.2016.155 Matsuo et al., J Pestic Sci, 2019 DOI: 10.1584/jpestics.D18-030
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Pyripyropene A (CAS: 147444-03-9)