Name: Radicicol
Brand: Biolinks K.K.
SKU: BLK-0500
Price: 36.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Radicicol (CAS: 12772-57-5) Product ID: BLK-0500 CAS 12772-57-5 Mechanism Hsp90 inhibitor Primary Target Hsp90 Pathway Protein folding pathway; Oncogenic signaling
Structure	View full structure page Chemical structure of Radicicol (CAS 12772-57-5)
CAS	12772-57-5
Molecular Formula	C18H17ClO6
Molecular Weight	364.78
UN (Transport)	UN2811
Price	1mg: USD 36.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	Monorden
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Data	1H NMR (CDCl3, 500 MHz) [View] [Full page] 13C NMR (CDCl3, 125 MHz) [View] [Full page]
NMR Spectral Data	Representative 1H NMR (CDCl3, 500 MHz) spectrum confirming the structure of Radicicol. Representative 13C NMR (CDCl3, 125 MHz) spectrum supporting structural assignment of Radicicol.
Source Organism	Pochonia sp.
Summary	Radicicol is a resorcylic acid lactone that inhibits Hsp90.
Details	Radicicol is a fungal secondary metabolite originally identified as an antibiotic and later established as a potent ATP-competitive inhibitor of heat shock protein 90 (Hsp90). It binds to the N-terminal ATP-binding pocket of Hsp90 and blocks its chaperone cycle, leading to destabilization and degradation of oncogenic client proteins including Raf-1, HER2, and mutant p53. Structural and biochemical studies confirmed its occupation of the nucleotide-binding site and its role in suppressing oncogenic signaling.
Browse Related	Mechanism Hsp90 inhibitor Open full index Primary Target Hsp90 Open full index Pathway Protein folding pathway; Oncogenic signaling Open full index Chemical Class Resorcylic acid lactone (RAL) Open full index
Mechanism	Hsp90 inhibitor
Primary Target	Hsp90
Pathway	Protein folding pathway; Oncogenic signaling
Chemical Class	Resorcylic acid lactone (RAL)
Discovery Year	1953
Keywords	hsp90 inhibitor resorcylic acid lactone atp-competitive inhibitor oncogenic client protein degradation inducer fungal macrolide chemical biology probe
References	Delmotte et al., Nature, 1953 DOI: 10.1038/171344a0 Schulte et al., J Biol Chem, 1998 DOI: 10.1074/jbc.273.25.15564 Soga et al., Cancer Res, 1998 DOI: 10.1158/0008-5472.CAN-98-0588 Roe et al., J Med Chem, 1999 DOI: 10.1021/jm990095i Chiosis et al., Mol Cancer Ther, 2001 DOI: 10.1158/1535-7163.MCT-01-0004
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Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.
Representative NMR Data 1H NMR (CDCl3, 500 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 13C NMR (CDCl3, 125 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 1H NMR (CDCl3, 500 MHz) 13C NMR (CDCl3, 125 MHz) Representative spectral data. Actual batch data may vary.

Radicicol (CAS: 12772-57-5)