Name: Fulvic Acid
Brand: Biolinks K.K.
SKU: BLK-0430
Price: 80.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Fulvic Acid (CAS: 479-66-3) Product ID: BLK-0430 CAS 479-66-3 Mechanism Tau aggregation inhibitor Primary Target Tau protein; p38 MAPK; JNK Pathway Tau aggregation pathway; MAPK signaling pathway
Structure	View full structure page Chemical structure of Fulvic Acid (CAS 479-66-3)
CAS	479-66-3
Molecular Formula	C14H12O8
Molecular Weight	308.25
Price	1mg: USD 80.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Fulvic Acid. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Fulvic Acid.
Source Organism	Penicillium sp.
Summary	Fulvic Acid is a fungal-derived phenolic humic substance that inhibits tau aggregation and modulates inflammatory signaling.
Details	Fulvic acid is a low-molecular-weight phenolic humic substance originally identified as a fungal metabolic product and later recognized as a bioactive natural compound. It inhibits tau protein fibril formation and promotes disassembly of preformed paired helical filaments associated with Alzheimer's disease. Additionally, fulvic acid downregulates inflammatory chemokines CCL17 and CCL22 by inhibiting p38 MAPK and JNK phosphorylation, attenuating Th2-driven inflammation in atopic dermatitis models. These combined neuroprotective and anti-inflammatory effects position fulvic acid as a multifunctional natural product scaffold for chronic inflammatory and neurodegenerative disease research.
Browse Related	Mechanism Tau aggregation inhibitor Open full index Primary Target Tau protein; p38 MAPK; JNK Open full index Pathway Tau aggregation pathway; MAPK signaling pathway Open full index Chemical Class Humic phenolic compound Open full index
Mechanism	Tau aggregation inhibitor
Primary Target	Tau protein; p38 MAPK; JNK
Pathway	Tau aggregation pathway; MAPK signaling pathway
Chemical Class	Humic phenolic compound
Discovery Year	1935
Keywords	tau aggregation inhibitor p38 mapk pathway modulator jnk pathway modulator anti-inflammatory compound humic-derived phenolic substance neuroprotective research scaffold
References	Raistrick et al., Biochem J, 1935 DOI: 10.1042/bj0291102 Cornejo et al., J Alzheimers Dis, 2011 DOI: 10.3233/JAD-2011-110623 Wang et al., Molecules, 2023 DOI: 10.3390/molecules28083507 Vucskits et al., J Diabetes Res, 2018 DOI: 10.1155/2018/5391014
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Fulvic Acid (CAS: 479-66-3)