Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data
Representative 1H NMR (500 MHz) spectrum confirming the structure of Cycloaspeptide A. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Cycloaspeptide A.
Source Organism
Gliocladium sp.
Summary
Cycloaspeptide A is a fungal cyclic peptide used as a nonribosomal peptide scaffold.
Details
Cycloaspeptide A is a nonribosomal cyclic peptide originally isolated from Penicillium species, including psychrotolerant and endophytic strains. Its structure was elucidated by NMR, MS, and X-ray crystallography in studies describing related cycloaspeptides. Although it exhibits low cytotoxicity and limited antibacterial activity, cycloaspeptide A represents a characteristic fungal NRPS-derived scaffold found in diverse ecological niches. It is primarily used as a chemical ecology and secondary metabolite research reference compound.