Name: Curvularin
Brand: Biolinks K.K.
SKU: BLK-0410
Price: 60.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Curvularin (CAS: 10140-70-2) Product ID: BLK-0410 CAS 10140-70-2 Mechanism Quorum sensing antagonist Primary Target RhlR quorum sensing regulator Pathway Quorum sensing pathway
Structure	View full structure page Chemical structure of Curvularin (CAS 10140-70-2)
CAS	10140-70-2
Molecular Formula	C16H20O5
Molecular Weight	292.33
Price	1mg: USD 60.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Curvularin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Curvularin.
Source Organism	Penicillium sp.
Summary	Curvularin is a fungal macrolactone polyketide acting as an RhlR quorum-sensing antagonist.
Details	Curvularin is a 12-membered macrolactone polyketide produced by various fungi including Penicillium and Phoma species. It selectively antagonizes the RhlR quorum-sensing regulator in Pseudomonas aeruginosa at low micromolar concentrations, suppressing pyocyanin and rhamnolipid production without impairing bacterial growth. By targeting RhlR rather than LasR, curvularin reduces virulence even in lasR-mutant strains and attenuates pathogenicity in Caenorhabditis elegans infection models. Beyond quorum-sensing inhibition, curvularin and its derivatives display antibacterial and cytotoxic activities, making it a valuable scaffold for anti-virulence drug development and quorum-sensing research.
Browse Related	Mechanism Quorum sensing antagonist Open full index Primary Target RhlR quorum sensing regulator Open full index Pathway Quorum sensing pathway Open full index Chemical Class 12-membered macrolactone polyketide Open full index
Mechanism	Quorum sensing antagonist
Primary Target	RhlR quorum sensing regulator
Pathway	Quorum sensing pathway
Chemical Class	12-membered macrolactone polyketide
Discovery Year	1959
Keywords	rhlr antagonist quorum sensing inhibitor anti-virulence agent macrolactone polyketide pseudomonas aeruginosa signaling modulator fungal metabolite qs research tool
References	Oxford & Raistrick, Biochem J, 1959 DOI: 10.1042/bj0730129 Kim et al., Front Microbiol, 2022 DOI: 10.3389/fmicb.2022.913882 Zhang et al., Phytochemistry, 2024 DOI: 10.1016/j.phytochem.2024.114000 Liu et al., Nat Prod Res, 2022 DOI: 10.1080/10286020.2022.2117168
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Curvularin (CAS: 10140-70-2)