Name: Aurodox
Brand: Biolinks K.K.
SKU: BLK-0340
Price: 140.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Aurodox (CAS: 12704-90-4) Product ID: BLK-0340 CAS 12704-90-4 Mechanism EF-Tu inhibitor Primary Target Elongation factor Tu (EF-Tu); Type III secretion system components Pathway Bacterial protein synthesis; Virulence regulation
Structure	View full structure page Chemical structure of Aurodox (CAS 12704-90-4)
CAS	12704-90-4
Molecular Formula	C44H62N2O12
Molecular Weight	810.99
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	Efrotomycin;Antibiotic X-5108
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Data	1H NMR (CD3OD, 500 MHz) [View] [Full page]
NMR Spectral Data	Representative 1H NMR (CD3OD, 500 MHz) spectrum confirming the structure of Aurodox. Representative 13C NMR (CD3OD, 125 MHz) spectrum supporting structural assignment of Aurodox.
Source Organism	Streptomyces sp.
Summary	Aurodox is a type III secretion system inhibitor with anti-virulence activity against Gram-negative pathogens.
Details	Aurodox is a linear polyketide natural product produced by Streptomyces goldiniensis and structurally related to kirromycin. It inhibits bacterial type III secretion systems (T3SS) in Gram-negative pathogens including EHEC, Salmonella, and Yersinia, while also targeting elongation factor EF-Tu. By suppressing virulence rather than bacterial growth, aurodox represents a promising anti-virulence strategy for antimicrobial resistance research.
Browse Related	Mechanism EF-Tu inhibitor Open full index Primary Target Elongation factor Tu (EF-Tu); Type III secretion system components Open full index Pathway Bacterial protein synthesis; Virulence regulation Open full index Chemical Class Elfamycin polyketide Open full index
Mechanism	EF-Tu inhibitor
Primary Target	Elongation factor Tu (EF-Tu); Type III secretion system components
Pathway	Bacterial protein synthesis; Virulence regulation
Chemical Class	Elfamycin polyketide
Discovery Year	1977
Keywords	type iii secretion system inhibitor ef-tu inhibitor anti-virulence compound polyketide antibiotic elfamycin class streptomyces natural product bacterial pathogenicity research tool
References	Zhu et al., Appl Environ Microbiol, 2022 DOI: 10.1128/aem.00692-22 Wallace et al., Open Biol, 2024 DOI: 10.1098/rsob.240240 Kinoshita et al., J Antibiot, 1977 DOI: 10.7164/antibiotics.30.244
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Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.
Representative NMR Data 1H NMR (CD3OD, 500 MHz) Representative spectral data. Actual batch data may vary.

Aurodox (CAS: 12704-90-4)