Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data
Representative 1H NMR (500 MHz) spectrum confirming the structure of Aspergillimide. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Aspergillimide.
Source Organism
Aspergillus japonicus.
Summary
Aspergillimide is an indole alkaloid from Aspergillus species with anthelmintic activity.
Details
Aspergillimide is a secondary metabolite produced by an Aspergillus species and belongs to a class of indole alkaloids structurally related to paraherquamides. It differs from paraherquamides by the loss of the dioxygenated seven-membered ring and the fused phenyl ring, instead possessing a C8-keto group. Aspergillimide exhibits anthelmintic activity and represents a structurally simplified scaffold within the paraherquamide family of nematocidal fungal metabolites.