MS-347a – Selective inhibitor of myosin light chain ...

For Research Use Only. Not for human or veterinary use.

MS-347a Product ID: BLK-1710
Structure
CAS	144678-18-2
Molecular Formula	C16H12O7
Molecular Weight	316.27
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Aspergillus udagawae.
Summary	MS-347a Fungal MLCK inhibitor used to study Ca2+-dependent cytoskeletal contraction.
Details	MS-347a is a fungal secondary metabolite isolated from Aspergillus sp. that irreversibly inhibits smooth muscle myosin light chain kinase (MLCK) with micromolar potency. The compound suppresses phosphorylation of myosin light chain by binding to the catalytic domain of MLCK and inhibits both calmodulin-dependent and -independent enzyme activity. MS-347a attenuates sustained Ca2+-dependent exocytosis and inositol trisphosphate signaling without broadly inhibiting other cyclic nucleotide-dependent kinases. It has been used as a mechanistic probe to dissect MLCK-mediated actomyosin regulation and calcium-controlled secretion pathways.
Mechanism	Selective inhibitor of myosin light chain kinase (MLCK), blocking Ca2+-dependent phosphorylation of myosin light chain.
Primary Target	Myosin light chain kinase (MLCK)
Pathway	Actomyosin contraction pathway; Calcium-dependent exocytosis
Chemical Class	Polyketide kinase inhibitor
Discovery Year	1993
Keywords	myosin light chain kinase inhibitorca2+-dependent exocytosis inhibitorirreversible kinase inhibitoraspergillus metaboliteactomyosin regulation research tool
References	Hayashi et al., J Antibiot, 1993 DOI: 10.7164/antibiotics.46.1775 Koshimizu et al., J Biol Chem, 1993 DOI: 10.1016/S0021-9258(17)37404-5 Naor et al., Endocrinology, 1997 DOI: 10.1210/endo.138.4.5078 Yamamoto et al., Biosci Biotechnol Biochem, 2024 DOI: 10.1093/bbb/zbae050
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