Amidepsine A – Inhibits diacylglycerol acyltransferase , ...

For Research Use Only. Not for human or veterinary use.

Amidepsine A Product ID: BLK-0311
Structure
CAS	169181-28-6
Molecular Formula	C29H29NO11
Molecular Weight	567.55
Price	1mg: USD 210.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Humicola sp.
Summary	Amidepsine A Fungal diacylglycerol acyltransferase (DGAT) inhibitor that suppresses triacylglycerol formation in lipid metabolism studies.
Details	Amidepsine A is a fungal depside metabolite produced by Humicola sp. FO-2942 and identified as an inhibitor of diacylglycerol acyltransferase (DGAT), a key enzyme in triacylglycerol biosynthesis. Structural elucidation by spectroscopic analyses including NMR established its detailed aromatic ester-amide architecture. Biological evaluation demonstrated inhibition of DGAT activity in rat liver microsomes with micromolar potency and suppression of triacylglycerol formation in intact Raji cells, confirming intracellular activity. These findings establish amidepsine A as a lipid metabolism modulator targeting DGAT-dependent triglyceride biosynthesis pathways.
Mechanism	Inhibits diacylglycerol acyltransferase (DGAT), suppressing triacylglycerol biosynthesis in microsomal and cellular systems.
Primary Target	Diacylglycerol acyltransferase (DGAT)
Pathway	Triglyceride biosynthesis; Lipid metabolism
Chemical Class	Depside
Discovery Year	1995
Keywords	diacylglycerol acyltransferase inhibitortriglyceride biosynthesis inhibitorlipid metabolism modulatortriacylglycerol formation suppressordidepside natural producthumicola metabolitedgat research tool
References	Omura S et al., J Antibiot (Tokyo), 1995, 48:937-941 DOI: 10.7164/antibiotics.48.937 Omura S et al., J Antibiot (Tokyo), 1995, 48:942-945 DOI: 10.7164/antibiotics.48.942
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