EM574 [Motilide] – Motilin receptor agonist that stimulates g...

For Research Use Only. Not for human or veterinary use.

EM574 [Motilide] Product ID: BLS-0510
Structure
CAS	110480-13-2
Molecular Formula	C39H69NO12
Molecular Weight	743.98
Price	1mg: USD 230.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	EM-574
Purity	>95%
Source Organism	Synthetic
Summary	EM574 [Motilide] Non-peptide erythromycin-derived motilin receptor agonist used to stimulate gastric motility.
Details	EM574 (de(N-methyl)-N-isopropyl-8,9-anhydroerythromycin A 6,9-hemiacetal) is a semisynthetic macrolide derived from erythromycin that functions as a potent motilin receptor agonist. It directly stimulates smooth muscle contraction in the human and rabbit gastric antrum by binding to motilin receptors with nanomolar affinity. In vivo studies demonstrate that EM574 enhances antral motility and accelerates gastric emptying, including in gastroparesis models, via cholinergic pathways. EM574 serves as a prototypical motilide and is widely used as a pharmacological tool to study motilin receptor signaling and gastrointestinal prokinetic mechanisms.
Mechanism	Motilin receptor agonist that stimulates gastrointestinal smooth muscle contraction.
Primary Target	Motilin receptor (MLNR)
Pathway	Motilin signaling pathway; Gastrointestinal motility regulation
Chemical Class	Macrolide (motilide class)
Discovery Year	1996
Keywords	motilin receptor agonistgastroprokinetic agentgastric motility stimulatorerythromycin-derived macrolidegastrointestinal smooth muscle activatormotilide analogprokinetic research tool
References	Peeters et al., J Pharmacol Exp Ther, 1996 DOI: 10.1016/S0022-3565(25)22837-3 Takeuchi et al., Eur J Pharmacol, 1997 DOI: 10.1016/S0014-2999(96)00983-1 Fujimiya et al., Eur J Pharmacol, 2000 DOI: 10.1016/S0014-2999(00)00185-0
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