Atpenin A5 – Highly specific inhibitor of mitochondrial...

For Research Use Only. Not for human or veterinary use.

Atpenin A5 Product ID: BLS-0330
Structure
CAS	119509-24-9
Molecular Formula	C15H21Cl2NO5
Molecular Weight	366.24
UN (Transport)	UN2811
Price	1mg: USD 250.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Synthetic
Summary	Atpenin A5 Highly specific mitochondrial complex II inhibitor used in bioenergetics research.
Details	Atpenin A5 is a chlorinated fungal metabolite isolated from Penicillium species. It is a potent and specific inhibitor of mitochondrial complex II (succinate-ubiquinone oxidoreductase), binding to the quinone-binding pocket of succinate dehydrogenase. Atpenin A5 is widely used as a biochemical tool to investigate electron transport chain function, mitochondrial bioenergetics, reactive oxygen species production, and metabolic reprogramming in mammalian cells. It has also contributed to structural elucidation of the complex II quinone-binding site.
Mechanism	Highly specific inhibitor of mitochondrial complex II (succinate dehydrogenase) that binds the quinone-binding site, blocking electron transfer.
Primary Target	Succinate dehydrogenase (Complex II)
Pathway	Mitochondrial electron transport chain; TCA cycle
Chemical Class	Chlorinated polyketide
Discovery Year	1988
Keywords	mitochondrial complex ii inhibitorsuccinate dehydrogenase inhibitorquinone-binding site bindermitochondrial respiration inhibitorelectron transport chain inhibitoroxidative phosphorylation modulatorfungal metabolitebioenergetics research tool
References	Uchida et al., J Antibiot, 1988 DOI: 10.7164/antibiotics.41.1769 Miyadera et al., PNAS, 2003 DOI: 10.1073/pnas.0237315100 Horsefield et al., J Biol Chem, 2006 DOI: 10.1074/jbc.M508173200
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