Aurodox – Inhibits elongation factor Tu and suppress...

For Research Use Only. Not for human or veterinary use.

Aurodox Product ID: BLK-0340
Structure
CAS	12704-90-4
Molecular Formula	C44H62N2O12
Molecular Weight	810.99
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	Efrotomycin;Antibiotic X-5108
Purity	>95%
Source Organism	Streptomyces sp
Summary	Aurodox Type III secretion system inhibitor with anti-virulence activity against Gram-negative pathogens.
Details	Aurodox is a linear polyketide natural product produced by Streptomyces goldiniensis and structurally related to kirromycin. It inhibits bacterial type III secretion systems (T3SS) in Gram-negative pathogens including EHEC, Salmonella and Yersinia, while also targeting elongation factor EF-Tu. By suppressing virulence rather than bacterial growth, aurodox represents a promising anti-virulence strategy for antimicrobial resistance research.
Mechanism	Inhibits elongation factor Tu (EF-Tu) and suppresses bacterial type III secretion systems, blocking protein synthesis and virulence factor delivery.
Primary Target	Elongation factor Tu (EF-Tu); Type III secretion system components
Pathway	Bacterial protein synthesis; Virulence regulation
Chemical Class	Elfamycin polyketide
Discovery Year	1977
Keywords	type iii secretion system inhibitoref-tu inhibitoranti-virulence compoundpolyketide antibioticelfamycin classstreptomyces natural productbacterial pathogenicity research tool
References	Zhu et al., Appl Environ Microbiol, 2022 DOI: 10.1128/aem.00692-22 Wallace et al., Open Biol, 2024 DOI: 10.1098/rsob.240240 Kinoshita et al., J Antibiot, 1977 DOI: 10.7164/antibiotics.30.244
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