Calpinactam – Selective antimycobacterial hexapeptide; m...

For Research Use Only. Not for human or veterinary use.

Calpinactam Product ID: BLK-1100
Structure
CAS	1205538-83-5
Molecular Formula	C38H57N9O8
Molecular Weight	767.93
Price	1mg: USD 270.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Summary	Calpinactam Fungal hexapeptide active against Mycobacterium species.
Details	Calpinactam is a fungal hexapeptide metabolite isolated from Mortierella alpina FKI-4905. Structurally, it contains a unique C-terminal caprolactam ring and was characterized by detailed NMR analysis and total synthesis. Calpinactam exhibits selective antimycobacterial activity, inhibiting the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with low micromolar MIC values while showing minimal activity against other bacteria and fungi. Biosynthetic studies revealed that calpinactam is produced by a large nonribosomal peptide synthetase (NRPS), and heterologous expression systems have enabled its production from long fungal biosynthetic genes.
Mechanism	Selective antimycobacterial hexapeptide; molecular target not fully defined.
Primary Target	Not identified (Mycobacterium-selective activity)
Pathway	Mycobacterial growth inhibition
Chemical Class	NRPS-derived hexapeptide
Discovery Year	2010
Keywords	antimycobacterial peptidehexapeptide natural productcaprolactam-containing peptidemycobacterium tuberculosis inhibitornonribosomal peptide synthetase productmortierella metaboliteanti-tuberculosis lead compound
References	Ishikawa et al., Org Lett, 2009 DOI: 10.1021/ol902553z Ishikawa et al., J Antibiot, 2010 DOI: 10.1038/ja.2010.14 Geib et al., Fungal Biol Biotechnol, 2023 DOI: 10.1186/s40694-023-00152-3
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